Formulation and Development Floating Tablet of Anti Depressant (Venlafaxine Hydrochloride)

Abstract

The main object in this research study is development, formulation and evaluation of Venlafaxine hydrochloride antidepressant gastro retentive tablets that is release 24 h time of period in control manner. Floating drug delivery system use in treatment of depression is the main object on floating drug delivery system mechanism, needs and application and the main focus on used in treatment in depression mental state, floating drug delivery system is extreme valuable process and capability to prolong and control the gastric emptying time which domicile in the stomach for long time and floating system is more significance in enhancement of bioavailability and minimize the drug wastages, depression is most serious mental state today many people is know that depression not disease but it is serious mental disease which is cause anxiety etc. And floating drug delivery system is very useful on those drug which have lower bioavailability and in this disease. And in this mental state patients not want to take medicine two to three times because they not feel good and normal and floating system is most useful for Patients compliance so floating drug delivery system is very applicable in anti-depressant drug for example Venlafaxine hydrochloride. In this formulation used different type of the apply in this preparation which is HPMC, Carnauba wax, Sodium bi carbonate, cetyl alcohol, Talc, Olive oil as well as drug formulate and give satisfactory and optimal release and stay buoyant on the medium surface the conclusion is obtain success in this formulation and increase in bioavailability as well gastric residence time.