New insights from cardiac muscle applied to skeletal muscle

Abstract

I have recently described the origin of the second Ca2+ binding in the triggering of contractile activity in cardiac myo ibrils that is the origin of the Ca2+ Hill coef icient of 2 for the ATPase. This site is not a simple protein binding site and cannot be measured by 45Ca2+ binding. The myo ibril protein unit requirements are described by me and so are the consequences of disruption of the function of these units and the related medical outcomes. The purpose of this paper is to review the topic and extend the reasoning to the function of skeletal muscle and cite the literature that supports this.