Treatment and Nursing of a 90% Bullous Epidermal Necrolysis Drug Eruption Complicated with Diabetes, Hypoproteinemia and Bilateral Pneumonia

Abstract

Bullous epidermal necrolysis drug eruption is mainly caused by drug allergy, also known as toxic epidermal necrolysis, TEN, first reported by Lyell A in 1956, also known as Lyell syndrome, is the most serious type of drug eruption, the fatality rate is about 25%-50%. The disease is characterized by acute onset, obvious systemic toxic symptoms, and flaccid blisters of varying sizes on the skin of the whole body. At the beginning of the disease, the skin rash is dark red or dark red. It quickly fuses into flakes and develops into the whole body. There are flaccid blisters and epidermolysis in the lesions, which are slightly rubbed or broken, and the tenderness is obvious and accompanied by a large amount of exudation. Severe cases may involve various organs and tissues of the body, accompanied by oral, conjunctival, respiratory, gastrointestinal mucosa erosion, ulcer, some patients may have liver and kidney function damage, serious cases may die of infection, liver and kidney failure, toxicemia, electrolyte disorders or visceral bleeding. Article history Received: 16 December 2018 Revised: 23 December 2018 Accepted: 31 December 2018 Published: 31 January 2019