Differential expression of SCUBE2 in cancer of the vulva.

Abstract

In these brief notes we document work using published microarray data (1, 2) to pioneer integrative transcriptome analysis comparing vulvar carcinoma to its tissue of origin, the vulva. We report the differential expression of signal peptide, CUB domain and EGF-like domain-containing 2, encoded by SCUBE2, in cancer of the vulva. SCUBE2 may be of pertinence to understanding transformation and disease progression in vulvar cancer (3).