The Effect of Uric Acid and Bilirubin Levels on Type 2 Diabetes Mellitus Development in Prediabetic Patients

Abstract

Background: This study aims to investigate whether or not uric acid and bilirubin have a role in the \ndevelopment of type 2 diabetes mellitus (T2DM) in prediabetic patients. \nMethods: 93 patients were included in the study. These patients were diagnosed as being prediabetic \nusing the oral glucose tolerance test, and they also had their serum uric acid and total bilirubin measured \nduring the follow-up application (1 - 5 years). \nResults: 17 out of the 93 patients developed T2DM during the study period. The only significant \ndifference between the T2DM group and the non-T2DM group was OGTT 0.min and 120.min (p=0.001 \nand p=0.007, respectively). Analysis of the relationship between age, sex, HbA1c, uric acid, total \nbilirubin, direct bilirubin levels and T2DM development showed that none of the aforementioned risk \nfactors were related with diabetes development. In the non-T2DM group, the median total bilirubin level \nwas only found to be higher in the baseline assessment (p=0.042). \nConclusion: It was found that uric acid and bilirubin had no effect on the development of diabetes in the \n1-5-year follow-up of prediabetic patients. Randomized-controlled studies of a larger number of patients \nand sufficient follow-up time are required to provide clearer data on this topic.