Оценка некоторых клинико-патогенетических взаимосвязей у больных фибрилляцией предсердий в сочетании с артериальной гипертонией и экстракардиальной патологией

Abstract

A prospective cohort study included 173 men 45–65 years with arterial hypertension (AH) and atrial fi brillation (AF). The 1st group consisted 53 patients with abdominal obesity (AO) and with diabetes mellitus of type 2; the 2nd group consisted 64 patients with AO without diabetes mellitus; the 3rd group was the comparison one it included 56 patients with AH and AF without accompanied pathology. The studied groups differed on age: average of patients of the 1st and 2nd group was reliably senior, than in patients of the comparison group. During the comparison of biochemical parameters it was found that patients of the 1st and 2nd group had a signifi cant increase in potassium, creatinine, urea compared of the comparison group higher. The fi brosis marker galectin-3 was higher in patients of the 1st group then in patients of the control group. In patients of the 1st and 2nd group there was a signifi cant decrease of the index of mass a myocardium of the left ventricular (IMMLV) compared to patients of the comparison group. The decrease of the IMMLV with concomitant comorbid pathology may be associated with metabolic processes that can slow compensatory muscular hypertrophy of the myocardium. Thus, patients with atrial fi brillation on the background of arterial hypertension, abdominal obesity and diabetes mellitus needed early diagnostics and correction of both AH and extracardial comorbid diseases in order to prevent early and rapidly progressive myocardial lesions.