Assessment and Interrelation of hs-CRP, Nitrosative Stress and Lipid Profile in Type-2 Diabetes Mellitus

Abstract

Introduction: The prevalence of type 2 Diabetes Mellitus, one of the major health problems, is increasing day by day, which is one of the important causes for the development of Cardiovascular Disease (CVD). Aim: To determine serum levels of hs-CRP, total nitrite, endogenous nitrite, Nitrate/Nitrite ratio and Lipid Profile as predictors of inflammation, nitrosative stress and dyslipidemia in Type 2 Diabetes Mellitus patients and to evaluate the correlation among the above mentioned biochemical parameters with age-sex matched healthy controls. Materials and Methods: Current study was designed to estimate the level of fasting blood sugar, hs-CRP, parameters of lipid profile and different parameters of nitrosative stress (total nitrite, endogenous nitrite, nitrate and nitrate/nitrite ratio)in the Department of Biochemistry on diabetics screened from Department of Endocrinology and Metabolism, through proper inclusion and exclusion criteria, and compared with that of age-sex matched healthy controls. Result: Level of total nitrite, nitrate, nitrate/nitrite ratio parameters of nitrosative stress, hs-CRP and total cholesterol, LDL-cholesterol, VLDL-cholesterol and triglyceride are significantly high in the group of diabetics and statistically significant as compared with controls. Conclusion: Assessment of hs-CRP, marker of low-grade inflammation and parameters of nitrosative stress is necessary for the diabetics as they are established independent potent risk factors for CVD. A large study population from multiple centres are required for a better result to conclude the study.