Молекулярная и функциональная гетерогенность Na,K-АТФазы в скелетной мышце

Abstract

Na,K-ATPase activity is critical for maintaining electrogenesis, contractile function and skeletal muscle performance. This review is devoted to the analysis of the results of recent studies in the field of molecular and functional diversity of Na,K-ATPase in skeletal muscle, co-expressing a1 and a2 isoforms of the catalytic and transport a subunit of Na,K-ATPase. The problems that seem to be the most promising from the point of view of their further development are considered. The accumulated facts indicate that, in contrast to the a1 isoform, which demonstrates functional stability, the a2 isoform is distinguished by a high degree of plasticity, which is due to its specific membrane localization, functional and molecular interactions with the protein and lipid environment, as well as the peculiarities of regulation by various factors. Functional disorders of the a2 isoform of Na,K-ATPase are among the most common signs characteristic of both chronic and short-term forms of motor dysfunction.