UJI DAYA ANTIINFLAMASI EKSTRAK ETANOLIK KULIT TERONG BELANDA (Solanum betaceum, Cav.) PADA MENCIT JANTAN YANG DIINDUKSI KARAGENIN

Abstract

ABSTRACT \nInflammation is a normal response to injury due to release of chemical mediators such as \nprostaglandins. Solanum betaceum Cav. skin contains flavonoid compounds. This study aims to \ndetermine the antiinflammatory power and the effect of variations in the dose of ethanolic extract \nof the skin of Solanum betaceum Cav on Swiss male strain mice caragenin-induced. The ethanolic \nextract of Solanum betaceum Cav skin was obtained using remaseration method with 96% ethanol \nsolvent. Antiinflammatory power test using edema formation method with induction of caragenin \n1% intraplantar 30 minutes before administration of the test material. Tests were carried out on 25 \nmice records which were divided into 5 groups namely negative control (0.5% CMC Na \nsuspension), positive control (diclofenac sodium suspension in 0.5% CMC Na dose 7 mg/kgBW) \nand given suspension respectively. Dutch eggplant skin ethanolic extract in CMC Na 0.5% dose 70 \nmg/kgBW; 140 mg/kgBW; 280 mg/kgBW orally. The parameters observed were edema thickness \nmeasured using calipers at 30 minute intervals for 360 minutes. The results of edema thickness difference are used to calculate the Area Under Curve (AUC) and the percentage of \nantiinflammatory power (% AIP). Dat a were analyzed statistically with the One Way Anova test \nand continued by the Post Hoc Test with a 95% confidence level. The results showed that the \nethanolic extract of Solanum betaceum Cav skin contains flavonoid compounds and has \nantiinflammatory power. The greater the dose of ethanolic extract of Solanum betaceum Cav skin, \nthe greater the anti-inflammatory power.