Journal of Alzheimer s disease : JAD | 2021
Pre-Dementia Stages and Incident Dementia in the NuAge Study.
Abstract
BACKGROUND\nMotoric cognitive risk syndrome (MCR) and mild cognitive impairment (MCI) are two pre-dementia stages with an overlap, which may influence the risk for dementia.\n\n\nOBJECTIVE\nThe study aims to examine the association of MCR, MCI, and their combination with incident dementia in Quebec community-dwelling older adults.\n\n\nMETHODS\n1,063 older adults (i.e., ≥65) were selected from a population-based observational cohort study known as the Nutrition as a determinant of successful aging: The Quebec longitudinal study (NuAge). Participants were separated into four groups at the baseline assessment: those without MCR and MCI, those with MCR alone, those with MCI alone, and those with MCR plus MCI. Incident dementia was recorded at each annual visit during a 3-year follow-up.\n\n\nRESULTS\nThe prevalence of CHI was 87.2% , MCR 3.0% , MCI 8.8% , and MCR plus MCI 0.9% . The overall incidence of dementia was 2.3% and was significantly associated with MCR alone (Odd Ratio (OR)\u200a=\u200a5.00 with 95% Confidence interval (CI)\u200a=\u200a[1.01;24.59] and p\u200a=\u200a0.049), MCI alone (OR\u200a=\u200a6.04 with 95% CI\u200a=\u200a[2.36;15.47] and p≤0.001), and the combination of MCR and MCI (OR\u200a=\u200a25.75 with 95% CI\u200a=\u200a[5.32;124.66] and p≤0.001).\n\n\nCONCLUSION\nCombining MCR and MCI increased the risk for incident dementia. These results also demonstrated that this combination is a better predictor of dementia than MCI and MCR alone.