Archive | 2021
Current Strategies for The Disruption and Inhibition ofOral Biofilm Formation
Abstract
Oral biofilm, an organized community comprises of extensive\nvariety of microbes rooted with extracellular polysaccharides\n(EPS) matrix. It is recognized as a virulence factor to numerous oral\ninfectious diseases including dental caries, gingivitis, periodontitis,\nperiapical periodontitis and peri-implantitis [1]. Biofilm formation\non medical devices such as mechanical heart valves, catheters,\ncontact lenses and prosthetic joints pose a critical medical problem.\nBoth gram positive and negative bacteria can form biofilms on\nmedical devices. Medical device infections are accountable for\nalmost 60% of hospital acquired infections. In the United States,\nthe anticipated expense of caring for healthcare-associated\ninfections is nearly between $28 billion and $45 billion each year\n[2]. The lifecycle of a conventional biofilm comprises of bacterial\nattachment, biofilm growth/maturation, and biofilm dispersion.