Pengaruh mometasone furoate terhadap kadar Interleukin 6 serum padapenderita hipertrofi adenoid

Abstract

Latar belakang:\xa0 Inflamasi adenoid ditandai dengan ditemukannya pembesaran ukuran adenoid atau hipertrofi adenoid. Telah banyak dilakukan penelitian yang mendukung IL-6 merupakan dasar patofisiologi terjadinya hipertrofi adenoid sehingga dibutuhkan terapi yang dapat mengurangi peran IL-6. Saat ini, kortikosteroid intranasal menjadi pilihan terapi pada hipertrofi adenoid karena memiliki efek anti inflamasi. Terdapat penelitian mengenai manfaat penggunaan kortikosteroid intranasal terhadap penderita hipertrofi adenoid, dimana terjadi penurunan kadar IL-6, tetapi pengaruhnya terhadap kadar IL-6 serum tidak diteliti.\xa0 Tujuan:\xa0 Mengetahui pengaruh pemberian\xa0 mometasone furoate\xa0 semprot hidung terhadap kadar IL-6 serum pada penderita hipertrofi adenoid.\xa0 Metode:\xa0 One group pre and post test\xa0 design ini melibatkan 16 subjek. Dilakukan pemeriksaan foto polos\xa0 skull lateral soft tissue\xa0 dan pengambilan darah tepi untuk menghitung kadar IL-6 serum. Diberikan terapi\xa0 mometasone furoate semprot hidung selama 6 minggu. Setelah 2 minggu dan 6 minggu dilakukan pengambilan darah tepi untuk menghitung kadar IL-6 serum, serta evaluasi foto polos\xa0 skull lateral soft tissue\xa0 setelah 6 minggu.\xa0 Hasil: Terdapat perbedaan bermakna antara kadar IL-6 serum sebelum dan sesudah perlakuan baik, pada minggu kedua maupun minggu keenam (p=0.00). Terdapat perbedaan bermakna antara nilai foto polos\xa0 skull lateral soft tissue\xa0 sebelum dan sesudah perlakuan (p=0.00). Berdasarkan uji\xa0 Pearson , nilai kadar IL-6 serum darah berkorelasi secara signifikan yang bersifat negatif (p<0,05) dengan foto polos\xa0 skull lateral\xa0 sebelum dan sesudah perlakuan dengan hasil -0,819 dan -0,692.\xa0 Kesimpulan:\xa0 Mometasone furoate semprot hidung dapat menurunkan kadar IL-6 serum pada penderita hipertrofi adenoid secara bermakna, disertai dengan mengecilnya ukuran adenoid, penurunan gejala dan keluhan penderita hipertrofi adenoid.\xa0 Kata kunci:\xa0 Hipertrofi adenoid, Interleukin 6,\xa0 Mometasone Furoate ABSTRACT\xa0 Background: Adenoid inflammation is characterized by adenoid hypertrophy (AH). Numerous studies had stated that Interleukin 6 (IL-6) is the pathophysiological basis for the occurrence of AH, thus, a therapy is needed to reduce the role of IL-6. Intranasal corticosteroid (IC) is the drug-of-choice for AH for its anti-inflammatory nature. Previous research had shown a decrease in IL-6 levels in adenoid tissue after IC administration, but its effect on IL-6 serum level had not yet been studied.\xa0 Purpose:\xa0 To find out the effect of Mometasone Furoate (MF) on IL-6 serum level in AH patients.\xa0 Methods:\xa0 One group pre and post test design, involving 16 subjects, underwent a soft tissue skull lateral plain x-ray, also a peripheral blood examination for IL-6 serum level. Afterwards, subjects were treated with MF nasal spray for 6 weeks. The IL-6 serum level was evaluated after 2 and 6 weeks, and the soft tissue x- ray was assessed after 6 weeks.\xa0 Results:\xa0 There were significant differences between IL-6 serum levels before and after treatment both in the second and sixth week (p = 0.00). There were significant differences between the value of soft tissue skull lateral plain x-ray before and after treatment (p = 0.00). Based on the Pearson test, IL-6 serum levels correlated significantly negatively (p <0.05) with soft tissue skull lateral plain x-ray before and after treatment with results -0.819 and -0.692.\xa0 Conclusion:\xa0 MF nasal spray significantly reduce IL-6 serum levels in AH patients, reducing adenoid size and decreasing symptoms of AH patients.