OVEREXPRESSION VASCULAR ENDOTHELIAL GROWTH FACTOR IN NASOPHARYNGEAL CARCINOMA WITH UNDIFFERENTIATED CARCINOMA TYPE IN ADVANCED STAGE

Abstract

Introduction: \nNasopharyngeal Carcinoma (NPC) is a malignancy that tends to diagnosed at an advanced stage with low survival and prognosis rate. One of the factors that may play a role in progressivity and metastasis of tumor is overexpression of vascular endothelial growth factor (VEGF), which is a key role in tumor angiogenesis. \nObjective: \nThis study aims to learn the expression of VEGF in NPC with Undifferentiated Carcinoma type and to learn the association pf VEGF Expression with tumor stage of NPC \nMethod: \nThis is a cross-sectional study performed in ENT-HNS Department of ENT-HNS of Udayana University/Sanglah Hospital. The sample was collected by consecutive nonprobability sampling, starting from January 2016. NPC patients underwent Histopathologic examination from a nasopharyngeal biopsy. The result is Undifferentiated Carcinoma. VEGF expression analyzed by red-brown stained cytoplasm. Data were analyzed by Spearman s Correlation Test Chi-Square test, and Paired Sample t-Test. \nResult: \nVEGF positive Expression was found in 27 of 28 (96.4%) Undifferentiated Carcinoma type of NPC cases. VEGF overexpression was found in 23 of 28 (82.4%) Undifferentiated Carcinoma type of NPC cases.There is significant correlation found between tumor stage and VEGF expression (p<0.05). \nConclusion: \nFrom the research, it could conclude that there is significant correlation between tumor stage and VEGF Expression.