Adenovirus Humano Tipo 36 (Ad36) se relaciona con un mejor perfil lipídico en niños Mexicanos pero no con obesidad

Abstract

Introduccion . La obesidad y su comorbilidad son de las principales causas de muerte en Mexico, es una enfermedad multifactorial, en la que se ha visto ademas la participacion de un agente infeccioso. Ad36 se ha asociado con obesidad, pero paradojicamente tambien con niveles mas bajos de glucosa, colesterol y trigliceridos, sin embargo, existe controversia en diferentes poblaciones. Objetivo . Evaluar la asociacion de anticuerpos antiAd36 con variables antropometricas y bioquimicas. Material y metodos . Estudio transversal en 299 ninos mexicanos mestizos en edad escolar (6 a 12 anos). Se obtuvieron mediciones antropometricas de altura, peso corporal, circunferencia de la cintura, grosor del pliegue cutaneo del triceps, se calculo indice de masa corporal (IMC) y relacion cintura/ altura. Las variables bioquimicas incluyeron niveles sericos de glucosa, trigliceridos, colesterol total, lipoproteinas de alta densidad y lipoproteinas de baja densidad. Se utilizo un ensayo inmunoabsorbente ligado a enzimas (ELISA) para determinar los anticuerpos contra Ad36 en las muestras de suero. Resultados . Los anticuerpos anti-Ad36 se asociaron con niveles mas bajos de colesterol serico total (β = -0.133, p = 0.021) y LDL (β = -0.166, p = 0.004), y con niveles mas altos de HDL (β = 0.120, p = 0.037), pero no con obesidad. Conclusion. En resumen, la exposicion previa a Ad36 se asocio con un mejor perfil lipidico en ninos mexicanos, independientemente de la obesidad Background. Obesity and its comorbidities are one of the main causes of death in Mexico; it is a multifactorial disease, in which the participation of an infectious agent has been evaluated. Ad36 is associated with obesity, but paradoxically also with lower levels of glucose, cholesterol and triglycerides; however, there is controversy in different populations. Objective . To evaluate the association of antibodies against Ad36 with anthropometric and biochemical variables. Material and Methods . Cross-sectional study in 299 Mexican-mestizo children of elementary schools (6-12 years old). Anthropometric measurements of height, body weight, waist circumference, thickness of the triceps skin fold were obtained; body mass index (BMI) and waist / height ratio were calculated. Biochemical variables included serum glucose, triglycerides, total cholesterol, high-density lipoproteins, and low-density lipoproteins. An enzyme-linked immunosorbent assay (ELISA) was used to determine antibodies against Ad36 in serum samples. Results . Anti-Ad36 antibodies were associated with lower levels of total serum cholesterol (β = -0.133, p = 0.021) and LDL (β = -0.166, p = 0.004), and with higher levels of HDL (β = 0.120, p = 0.037), but not with obesity. Conclusion . Previous exposure to Ad36 was associated with a better lipid profile in Mexican children, regardless of obesity