Radical Radiotherapy of Locally Advanced Cervix Uteri Carcinoma

Abstract

8 Cervix uteri carcinoma is the most common gynecological cancer worldwide. In addition, it is the fourth most common malignancy and the fourth leading cause of cancer-related death in women [1]. The most common histopathological subtype is squamous cell carcinoma (85%). Non-squamous cell carcinoma is less common and is associated with poor prognosis. From 36% to 50% of cervix uteri carcinoma patients are diagnosed in a locally advanced stage (International Federation of Gynecology and Obstetrics [FIGO] stage IB2-IVA) [2]. Based on the results of five randomized-controlled trials, locally advanced cervix uteri carcinoma (LACC) is treated with radical radiotherapy (RT) [3-7]. Radical RT includes external beam radiotherapy (EBRT) with concomitant platinum-based chemotherapy (CHT) followed by brachytherapy (BRA) [8].