Legal Frameworks and Controls for the Protection of Research Animals: A Focus on the Animal Welfare Body with a French Case Study

Abstract

Simple Summary Worldwide, the conditions governing the use of laboratory animals are based on culture and traditions. Applications of the principle of the three Rs—replacement, reduction, and refinement—aim to foster humane and responsible science and minimize animal harm. In this paper, the European system regulating laboratory animal welfare is examined since it is one of the strictest such systems in the world. Growing public concern over the use of animals for research animal use and the importance of high research animal welfare to the outcomes of studies have pushed institutions to strengthen their protocols for research activities involving animals. The animal welfare body (AWB) is a type of regulatory structure responsible for protecting animal well-being in each stage of experimental research programs. It is a local structure that fulfills oversight and advisory functions on animal housing conditions and care and research procedures involving animals while providing support for the implementation of legal requirements. Since this structure is an innovation and examples of its functioning are scarce, a French case study is described here. Information on AWB members’ functions, tasks and goals is discussed by examining the body’s activity in a French research institute. The purpose of this work is to add knowledge in this field and share information on the scientific community’s commitment to welfare progress for laboratory animals. Abstract In recent years, efforts have been devoted to improving the welfare of laboratory animals. Scientific progress and growing concerns over animal harm have pushed institutions to strengthen their laws to make science more humane and responsible. European Directive 2010/63/EU makes it mandatory for breeders, suppliers and users of laboratory animals to have an animal welfare body (AWB) to prioritize animal welfare and harmonize experimental standards while reassuring the public that research is being carried out appropriately. Based on application of the three Rs (refinement, reduction and replacement), these bodies provide staff with oversight and advisory functions to support compliance with the legal requirements on both animal housing and project realization. This review aims to present the legal measures protecting research animals, with a focus on European AWBs. The review explains how the mission of AWBs includes development of environmental enrichment programs and how animal training generates benefits not only for animal welfare but also for the research work environment and research quality. A French case study is conducted to provide the scientific community with an example of an AWB’s functioning and activities, share its achievements and propose some perspectives for the future.