Does PRGF Work? A Prospective Clinical Study in Dogs with A Novel Polylactic Acid Scaffold Injected with PRGF Using the Modified Maquet Technique

Abstract

Simple Summary PRGF is a concentration of autologous platelets in a small volume of plasma, which is performed in a specific way and is an accessible resource in veterinary medicine. The PRGF has multiple demonstrated properties as antimicrobial, analgesic and anti-inflammatory but their osteoinductivity potential is controversial. We decided to use PRGF in combination with a PLA bioresorbable scaffold (a specific type of implant with osteoconduction properties) performed by 3D printing, and personalized for each patient, to determinate if the PRGF can produce osteoinduction and as a result, a faster bone healing and a faster patient recovery. Furthermore, in this study PLA scaffolds are proposed as an alternative for metallic implants to avoid the problems that those can cause. The MMT was the technique selected for solving the RCrCL as it is a variant of TTA that follows the same principle for the correction of the patellar tendon angle to neutralize distractive forces; however, this technique needs a lower amount of metallic implants for the scaffold fixation. Abstract Tibial tuberosity advancement is a surgical technique to restore the dynamical stability in the knee by advancing the insertion of the patellar ligament, for which it is necessary to advance the tibial crest, being maintained in the desired position usually by a cage and metallic implants. The purpose of this study was to replace the cage with a polylactic acid biodegradable scaffold designed for each patient by 3D printing, inserting platelet-rich in growth factors (PRGF) to demonstrate its osteoinductive properties. To this end, we used the modified Maquet technique to reduce the amount of metal to a minimum. Fifty-three dogs finished the study. The control and PRGF groups did not present any statistically significant differences in terms of ossification degree (p > 0.001) but they demonstrated satisfactory ossification compared to previous publications, although in the PRGF group three of the scaffolds suffered complete reabsorption. The PRGF and control groups did not show any statistically significant differences in terms of lameness degree (p > 0.001). However, the PRGF group showed at the first control some analgesic and anti-inflammatory properties but they were not enough for reducing the functional recovery time in a significant way. The PRGF group did not show any complications or negative results associated with their use.