AKI in a Patient with Pyuria and an Alkaline Urine

Abstract

A 70-year-old man was admitted to hospital with AKI. One year earlier, he had prostatic adenocarcinoma treated by prostatectomy, external radiotherapy, and hormonotherapy. Then 4 months before admission, he developed obstructive AKI with thickening of the bladder wall, suspected to be of neoplastic origin. Cystoscopy revealed diffuse inflammation of the bladder and double-J stents were inserted. Bladder biopsies showed necrotic tissue with intense mononuclear leukocyte infiltration, but no evidence of neoplasia (Figure 1).\n\n\n\nFigure 1. \nHaematoxylin and eosin staining of bladder biopsies showing the mucosa devoid of epithelium and the replacement of the submucosa by a thick collagen layer containing inflammatory cells and calcium salts (×10 objective). \n\n\n\nOn admission, the patient …