Faculty Opinions recommendation of TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells.

Abstract

Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms Co-corresponding authors: Sanjeev Mariathasan, [email protected]; Shannon Turley, [email protected]; Richard Bourgon, [email protected]. *These authors contributed equally to this work. Author contributions SM, SJT, DN, JR, LF, IM, DSC, MG, CD, GDF, PSH, RB, TP contributed to the overall study design. SM, SJT, DN, YW, EEK, KY, YG, YS, SL, PE, MH, LS, DLH, PSH, RB performed the biomarker and statistical analyses. HK, CC, JZ, SS, DS, JH, JMG, AKP, KM conducted microscopy studies. SJT, AC, JA, RC designed all the preclinical experiments, SJT, AC, JA, RC, YY, CC, JZ, YS, SS, DS, JH, JMG, AKP, KM, JR, RADC analysed the corresponding preclinical data. SM, SJT, DN, IM, PSH, RB, TP wrote the paper. All authors contributed to data interpretation, discussion of results and commented on the manuscript. Additional information All raw sequencing data required for RNAseq analyses have been deposited to the European Genome-Phenome Archive under accession number EGAS#00001002556. In addition, the source code and processed data used for all analyses presented here have been made available in IMvigor210CoreBiologies, a fully documented software and data package for the R statistical computing environment (R Core Team, 2016. R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. https://www.r-project.org). This package is freely available under the Creative Commons 3.0 license and can be downloaded from http://research-pub.gene.com/IMvigor210CoreBiologies. Conflicts of interest Pontus Eriksson, Mattias Hoglund, Lawrence Fong, Stephen Santoro have no competing interests. HHS Public Access Author manuscript Nature. Author manuscript; available in PMC 2018 August 14. Published in final edited form as: Nature. 2018 February 22; 554(7693): 544–548. doi:10.1038/nature25501. A uhor M anscript