A new vaccination strategy to induce broad range immunity against influenza by using recombinant influenza virus encoding a murine cytokine

Abstract

Introduction: Influenza is an important public health problem due to its high transmissibility, the ability to cause serious illness and pandemic potential. Immunization is the main strategy to reduce the impact of influenza infections. However, the current vaccines are unable to confer broad range protection against other FLU isolates and subtypes. Therefore, is important to seek alternative vaccine approaches able to induce the heterosubtypic and long-term memory responses. In this context, the cytokine IL-Z (encoded) is an important target in the study of new vaccine adjuvants, since it is associated with homeostasis and cell survival.