MICROELEMENT PROFILE AND STRUCTURE OF REGIONALLYMPH NODES DURING SENILE INVOLUTION OF LYMPHOID TISSUE

Abstract

The microelement profile and structure of lymph nodes were studied in experiment using old Wistar rats by means of a morphological method and the X-ray fluorescent analysis with synchrotron radiation. Their special qualitative and quantitative status is formed in regional lymph nodes that reflect age-related dynamics of lymphoid tissue. The content of trace elements and the size of compartments differ in lymph nodes of different localization. Age-related modifications in a microelement profile are characterized by proliferation of lymphoid cells, development of compartments and initiation of a corresponding immune response at the level of regional lymph nodes with different contact to external environment. Localization of lymph nodes is one of conditions for realization of the principle of a regional determinant (regional specifics).