International journal of scientific research | 2021
EFFICACY OF INTRAVENOUS LIGNOCAINE VERSUS TOPICAL LIGNOCAINE IN ATTENUATION OF HAEMODYNAMIC SURGE DURING LARYNGOSCOPY AND INTUBATION IN PATIENTS UNDERGOING SURGERY UNDER GENERALANAESTHESIA - A SINGLE BLIND RANDOMIZED CONTROL STUDY
Abstract
The present study was undertaken to evaluate the ef\uf001cacy of intravenous lignocaine versus topical lignocaine for attenuating haemodynamic\nresponse during laryngoscopy and intubation in patients undergoing surgery under general anaesthesia. This single blind randomized control study\nwas done on sixty patients of either sex aged between 18 to 55 years, of American Society of Anesthesiologists (ASA) status class I undergoing\nelective surgery under general anesthesia with endotracheal intubation. Patients were randomly allocated into two groups (group A and group B).\nGroup A and Group B received intravenous preservative free lignocaine hydrochloride 2% 2 mg/kg and topical (nebulized) lignocaine\nhydrochloride 4% at 2mg/kg. Heart rate, systolic, diastolic and mean blood pressure was documented before administering premedication (T0), at\ntime of intubation (TI) and 1 min (T-1), 2 min (T-2) & 5 min (T- 5) after intubation. Attenuation in the HR , SBP, DBP, MBPwere found statistically\nsigni\uf001cant (P<0.05) in group B in comparison to the group A. So, to conclude, topical lignocaine 4% blunts haemodynamic response to\nlaryngoscopy and intubation better than intravenous lignocaine 2% when other confounding factors are eliminated.