EVALUATION OF SERUM CREATININE LEVEL IN SUBCLINICAL\nHYPOTHYROIDISM

Abstract

Background: Hypothyroidism is a common endocrinal disorder caused by insuf\uf001cient production of\nthyroid hormones. Subclinical hypothyroidism (SCH) can be de\uf001ned as a state of high serum thyroid\nstimulating hormone (TSH) levels (less than 10µIU/ml) with normal serum free thyroxine (fT ) and triiodothyronine (fT ) levels in 4 3\nthe presence or absence of symptoms. Creatinine is a chemical waste product that is produced by muscle metabolism.\nCreatinine is produced from creatine, a molecule of major importance for energy production in muscles. Thyroid dysfunction\ncan affect renal physiology and development, and on the other hand, kidney disorders can in\uf002uence thyroid function. This\nstudy was aimed to \uf001nd out the status of serum fT , fT ,TSH and serum creatinine levels in subclinical hypothyroid cases and 3 4\nhealthy controls. Materials and Methods: The present study is descriptive case control study, was conducted in the Department\nof Biochemistry, J.L.N. Medical College and Associated group of Hospitals, Ajmer (Raj.). 130 cases of subclinical\nhypothyroidism attending Medical OPD of J.L.N. Hospitals were included and 50 age-sex matched euthyroid controls were\nselected. Results: The mean serum creatinine levels were found to be signi\uf001cantly high in subclinical hypothyroid cases(0.99\n+ 0.19 mg%) as compared to healthy controls (0.75 + 0.15 mg%), (p<0.0001). Conclusion: Serum creatinine can be used as a\nbiomarker for early detection of subclinical hypothyroidism in general population to prevent the morbidity and mortality which\nare associated with hypothyroidism. Early diagnosis and intervention of subclinical hypothyroid and their cluster of risk factor\ncan prevent the renal dysfunction.