COMPARISION OF VARIOUS DOSES OF INTRAVENOUSLY ADMINISTERED\nDEXMEDETOMIDINE WITH FENTANYL ON HAEMODYNAMICS TO INTUBATION\nIN PATIENTS UNDERGOING SURGERY UNDER GENERAL ANESTHESIA

Abstract

Background: During general anesthesia , direct laryngoscopy and intubation results in a profound\nsympathoadrenal response which leads to tachycardia , hypertension and in predisposed individuals\nmay lead to myocardial ischemia and arrhythmias. Various drugs such as opioids, lignocaine, propofol, beta blockers, alpha\nagonists have been used to minimize these adverse responses. Methods: 90 patients ASA1, ASA2 scheduled to undergo\nelective and emergency surgery under general anaesthesia were enrolled in double blind prospective randomized controlled\ntrial. ey were randomly allocated to one of the following groups. Group A received 2 micro gram/kg fentanyl intravenously10\nminutes before induction. Group B received 2 micro gram/kg fentanyl and 0.5 microgram/kg dexmedetomidine intravenously\n10 mins prior to induction. Group C received 2 mico gram/kg fentanyl and 1 microgram/kg dexmedetomidine i.v. 10\nminutes prior to induction. Results: Both study groups(B & C) were comparable with respect to there heart rate at base line, 1\nminute,2.5 minutes, 5 and 10 minutes after administration of the study drug. Group C(Dexmedetomidine 1 g) demonstrated a\ngreater suppression of chronotropic response to intubation as compared together two groups. Both the groups (B & C) were\ncomparable to their SBP at base line 5 and 10minutes Group C demonstrated a better suppression of the pressor response to\nintubation compared to other two groups