EFFICACY OF PROPHYLACTIC INTRAVENOUS ADMINISTRATION OF ONDANSETRON FOR PREVENTION OF SPINAL ANESTHESIA INDUCED HYPOTENSION IN ELDERLY PATIENTS

Abstract

Objective: Hypotension is the commonest side effect associated with spinal anesthesia. Multiple modalities have been\ntested to \uf001nd adequate preventive measure. Main objective of this study is to \uf001nd out the effectiveness of prophylactic\nadministration of inj. ondansetron for prevention of spinal anesthesia induced hypotension in elderly patients.Study design: Double blind,\nrandomized controlled trial. Place and duration of study: This study was conducted in our anesthesiology department from March 2020 to\nAugust 2020.Method: 100 patients were selected for the study using non-probability sampling technique, and divided into two groups of 50 each\nusing random numbers table. Each patient was preloaded with ringer s lactate solution in a dose of 10 ml/kg. Patients of Group A received 8 mg of\nondansetron IV \uf001ve minutes prior to administration of spinal anesthesia; whereas patients of Group B were injected normal saline IV. Data were\ncollected and analyzed using IBM SPSS version 20. Chi square test was used to compare hypotension between two groups. A p-value < 0.05 was\ntaken as signi\uf001cant. Results: Mean age of Group A was 64.16 ± 8.47 years, whereas that of Group B was 62.58 ± 8.99 (p value=0.39). Mean\nweight of Group A was 72.64 ± 5.82 kg, whereas that of Group B was 70.66 ± 5.96 kg (p - value=0.295). Hypotension was present in 23 (46%)\npatients in Group A, where as it was present in 34 (68%) patients in Group B (p value= 0.026). Bradycardia was recorded in 3(06%) vs.11(22%)\npatients in Group A and B respectively (p=0.021). Conclusion: We conclude that intravenous administration of 8 mg of ondansetron, 5 minutes\nprior to subarachnoid block, is effective in decreasing frequency of hypotension and bradycardia in elderly patients.