PLATELET VOLUME INDICES IN CHRONIC KIDNEY DISEASE

Abstract

Purpose:Chronic kidney disease is de\uf001ned as decreased kidney function shown by GFR of less than 60 mL/min per 1.73\nm2 or markers of kidney damage, or both, of at least 3 months duration, regardless of underlying cause. The best indicator\nof overall kidney function is estimated glomerular \uf001ltration rate (eGFR) evaluated using the MDRD formula.\nMethod: A cross sectional study was done wherein 142 cases of Chronic Kidney disease and 28 age matched healthy controls were enrolled.\n2 2 Cases were divided into 4 groups according to the estimated eGFR: Group – 1: 60-89 ml/ min/1.73m ; Group– 2: 30-59 ml/ min/1.73m ; Group -\n2 2\n3: 15-29 ml/ min/1.73m and Group - 4 : < 15 ml/ min/1.73 m . Complete blood count including platelet volume indices and laboratory\nparameters were estimated. Parameters were also compared by dividing cases in to 2 groups: eGFR low group= eGFR< 60 ml/minute/1.73m2\n2\nand GFR high group = GFR > 60 ml/min per 1.73m\nResults: Mean ages of CKD patients in males was 51.5±18.3 years and in females were 44.9±16.9 years with a male to female ratio as 1.84:1.\nPlatelet count, Mean platelet volume, Plateletcrit and Platelet distribution width showed signi\uf001cant difference between eGFR low and high\ngroup.\nConclusion: MPV and PDW were signi\uf001cantly higher in eGFR low group compared to eGFR high group which may explain the increase in\natherothrombotic risk in patients with slightly impaired renal function. Greater care is necessary during treatment of patients with higher MPVs,\nhowever further studies are required to establish the relationship between platelet indices and progression of CKD.