International journal of scientific research | 2021
CASE STUDY ON CIRCUMSCRIBED GLIOMAS, THEIR CLINICOPATHOLOGICAL CORRELATION IN A TERTIARY CARE CENTER
Abstract
The histogenesis and biological behavior of primary tumors of the central nervous system(CNS) are very diverse. The majority of present gliomas\nas benign, slow growing lesions classi\uf001ed as by the WHO classi\uf001cati grade I or II (Low grade gliomas) on of CNS tumors.\nHowever, a signi\uf001cant fraction of gliomas develop over a short period of time and progress rapidly and are therefore classi\uf001ed as WHO grade III\nor IV(High grade gliomas).\nAstrocytomas are primary central nervous system tumours that can develop in adults or in children. They arise from the Astrocytes. They can be\ndivided into diffuse that generally have a higher grade and poorer prognosis and those that are localised that tend to be of a lower grade and have a\nbetter prognosis.\nIn this study, we outline the basic histological spectrum and features, epidemiological aspects and grade of circumscribed gliomas (localised) or\nother Astrocytic tumours according to WHO classi\uf001cation . These are the Pilocytic Astrocytoma, Pilomyxoid Astrocytoma, Subependymal giant\ncell Astrocytoma, Pleomorphic xanthoastrocytoma and Anaplastic astrocytoma . The knowledge of these tumours are important as they are one of\nthe commonest cause of mortality and morbidity in both the young and old, accounting for about 60% of the glial tumours. Therefore\nneuropathological diagnosis and tumour characteristics will therefore profoundly in\uf002uence the impact of treatment strategies.