COMPARISON OF EFFECTIVENESS AMONG ONDANSETRON, PALONOSETRON\nAND GRANISETRON IN PREVENTING POSTOPERATIVE NAUSEAAND VOMITING\nFOLLOWING LAPAROSCOPIC CHOLECYSTECTOMY

Abstract

Postoperative nausea and vomiting (PONV) has been variously described as the “big little problem” the “\uf001nal therapeutic challenge” for\nanaesthesiology. The commonest cause of morbidity after anaesthesia and surgery are pain and postoperative nausea vomiting\n1. To compare the incidences of PONV following laparoscopic cholecyetectomy in different groups of patients receiving ondansetron,\npalonosetron and Granisetron.\n2. To identify the better strategy for prevention of PONV.\nThis is a prospective randomized double blinded clinical study. Both patient and observer were blinded to the group allocation. Allocations to three\ngroups were strictly con\uf001dential and concealed. One and half year (18 months). Patients undergoing elective laparoscopic cholecystectomy under\nGeneral Anaesthesia at General Surgery operation theatres of Bankura Sammilani Medical College and Hospital, Bankura The effects of\npalonosetron, granisetron and ondansetron in preventing PONV (postoperative nausea vomiting) were compared in patients undergoing\nlaparoscopic cholecystectomy and it was found that palonosetron was best and granisetron better in comparison with ondansetron in preventing\npostoperative nausea and vomiting. Palonosetron provides more effective prophylaxis of early PON (postoperative nausea), late PON\n(postoperative nausea), and late POV (postoperative vomiting) compared with granisetron and ondansetron. Palonosetron could provide effective\nprophylactic antiemetic control to prevent PONVafter laparoscopic cholecystectomy surgery under general anesthesia.