COMPARATIVE STUDY OF DEXMEDETOMIDINE AND FENTANYL ON\nHAEMODYNAMIC RESPONSES DURING LARYNGOSCOPY AND\nPNEUMOPERITONEUM IN LAPAROSCOPIC CHOLECYSTECTOMY

Abstract

INTRODUCTION: Laparoscopic surgeries form an essence of today s surgical practice because of its magni\uf001cation, dexterity, less cosmetic scar,\nless postoperative pain, and decreased hospital stay along with less morbidity and mortality. Laparoscopic cholecystectomy has become the gold\nstandard for gall bladder diseases. It is termed as patient friendly surgery because of less postoperative pain, shorter hospitalization and faster\nfunctional recovery along with other advantages of laparoscopic procedures.\nAIMS AND OBJECTIVES: Aims and objectives of this study are comparison of dexmedetomidine and fentanyl in attenuating hemodynamic\nchanges that occur due to laryngoscopy and endotracheal intubation. Comparison of dexmedetomidine and fentanyl during creating\npneumoperitoneum in laparoscopic cholecystectomy. We will observe the change in systolic blood pressure as well as diastolic and mean blood\npressure and pulse rate on both occasions. Adverse reaction of these two drugs.\nMATERIALS AND METHOD: This prospective, randomized, single blind placebo controlled study was done after approval of the\nEthics cum Screening Committee of KPC Medical College and Hospital, Jadavpur, Kolkata. The study was carried out in the NEW OT\nCOMPLEX in the KPC Medical College and Hospital during the period from March 2016- Oct 2017.\nA total of 60 patients of ASA physical status I and II were selected for this study. Standard dropout rates were taken into consideration. They were\ndivided into two groups, Group F (n=30) in which patients received fentanyl and Group D (n=30) in which patients received dexmedetomidine.\nRESULT AND ANALYSIS: Our study showed that the t-test showed that there was no signi\uf001cant difference in mean of the patients of the two\ngroups (p>0.05). Also 2c test showed that there was no signi\uf001cant difference in gender of the patients of the two groups (p=0.55). All the patients in\nboth the groups were with ASAGrade-I & II. Thus the patients of the two groups were matched for all demographic parameters. t-test showed that\nthe mean heart rate of the patients of Group-F was signi\uf001cantly higher than that of Group-D for all the time intervals except at 15 minutes before\ninduction and HR Just before induction (p<0.0001).\nCONCLUSION: Dexmedetomidine is also better in attenuating the hemodynamic surge during pneumoperitoneum. Incidence of adverse effects\nlike Post operative nausea and vomiting is more in Fentanyl group than dexmedetomidine group