Paripex Indian Journal Of Research | 2021
THE EFFECT OF OXYBUTYNIN ON\nNEUROGENIC DETRUSOR OVERACTIVITY IN\nSPINAL CORD INJURY PATIENT: A HOSPITAL\nBASED INTERVENTIONAL STUDY
Abstract
Neurogenic bladder dysfunction is one of prominent impairments following Spinal Cord Injury (SCI) and is seen in 90%\nof patients.This study has been undertaken to correlate the effect of anticholinergic drug (oxybutynin) on urodynamic\nparameters in neurogenic bladder of SCI patients.This is a hospital based non randomized prospective interventional\nstudy.After initial baseline urodynamic study,patients with detrusor areflexia were excluded from the study group and\nthirty patients showing detrusor overactivity and detrusor sphincter dyssynergia were treated with oral oxybutynin 5\nmg for 7 days followed by repeat urodynamic evaluation thereafter.Our study concluded that mean bladder compliance\nimproved from 6.114 to 17.95 ml/cmH2O after intervention and mean bladder capacity also increased after intervention\n(229.7ml) from (165.3ml) and changes were statistically significant.Antimuscarinic (Oxybutynin) is an effective drug in\nmanagement of neurogenic bladder in SCI patients increases bladder compliance and capacity and results are\nobjectively achieved within seven days