“RESPIRATORY VIRAL INFECTION: AN UNDERRATED ENTITY THAT NEED TO CONSIDER IN MANAGEMENT OF ACUTE EXACERBATION OF COPD”

Abstract

BACKGROUND: Acute exacerbation of COPD (AECOPD) is one of the most common cause of hospital admission. It\ncauses signi\uf001cant morbidity, mortality and inexorable decline in ling function. Many exacerbations are believed to be due\nto upper and/ lower respiratory tract viral infections, but the incidence of these infections in patients with COPD is still undetermined. Objectives\nof the study are-(a) To \uf001nd out the viral etiology in patients having acute exacerbation of COPD. (b) To correlate the severity of COPD patients\nhaving exacerbations with viral etiology.\nMETHODS: This cross-sectional study was carried out on 70 AECOPD patients admitted in department of Respiratory Medicine, Institute of\nRespiratory Diseases, SMS Medical College, Jaipur during July 2019–June 2020. Demographic and clinical parameters were recorded from\neach patient during admission. Twin nasopharyngeal/oropharyngeal swabs were collected and are tested for Respiratory viruses via RT-PCR.\nRESULTS: Respiratory viruses were detected in 15 of 70 (21.42%) patients during exacerbations of COPD. The viruses detected were\nin\uf002uenza (10%), rhinovirus (5.71%), adenovirus (4.29%) and RSV (1.42%). Majority of the patients had exacerbations in severe COPD\nsubgroup, had duration of hospital stay of more than or equal to 5 days, had one episode of acute exacerbation per year and 5, 9, 11 respiratory\nviruses were detected in this group respectively.\nCONCLUSION: Viral infections seem to contribute to the exacerbations of COPD in our settings and should be strongly considered in the\nmanagement of such patients. Considering appropriate antiviral therapy can timely reduce morbidity in an event of an in\uf002uenza viral\nexacerbation.