Annals of Tropical Medicine and Public Health | 2021
A cross sectional study to find out the lipid abnormalities and thyroid profile variations among SARS COVID-19 patients
Abstract
Background: SARS-CoV-2 viruses are a group of viruses which are responsible for the present pandemic. The clinical presentation of this pandemic has been varied from simple flu like symptoms to severe pneumonia. It is also found to affect multiple organ systems in our body. The aim of this study was to find out the variations in the levels of ferritin, lipid profile and thyroid hormone status among SARS Covid19 patients. Materials &methods: This retrospective cross sectional study was done among 312 SARS Covid-19 patients admitted in Chettinad hospital and research Institute during the time period of July-August 2020. Ferritin values, TC (Total cholesterol),TGL(Triglycerides),HDL(High Density Lipoprotein), LDL(Low Density Lipoprotein) and thyroid hormone levels, TSH(Thyroid Stimulating Hormone) FT3(Free Thyroid Hormone)and FT4(FreeT4)were measured among SARS Covid-19 patients. Results: The patients were divided into those admitted in ICU (190) and ward(122). In this study we found out a statistically significant difference in the levels of ferritin,(ward-(439.22+/380.5) and ICU -542+/-407.34) HDL(High Density Lipoprotein),(ward-33.8+/-15.74 and ICU31.04+/-11.78) and TSH(Thyroid Stimulating Hormone)(ward -2.7+/-8.83 and ICU-1.42+/-2.38) levels between patients admitted in ICU and ward. Pearson’s correlation analysis showed a significant positive correlation between ferritin with total cholesterol levels(r value-0.2067,P-value-0.0003),triglycerides(r value-0.336,p value-0.00001),and LDL levels (r value0.16 ,P-value-0.003). Conclusion: Lipid profile shows significant alterations in SARS Covid-19 patients.HDL GOpalakrishnanan et al (2020): Profiling SARS COVID-19 patients Dec, 2020 Vol. 23 Issue 23 Annals of Tropical Medicine & Public Health http://doi.org/10.36295/ASRO.2020.232396 levels show a promising role in diagnosing the severity of SARS Covid-19 cases.TSH levels showed a significant difference in the levels between the patients admitted in ICU and ward showing the role of inflammation in the pathogenesis of thyroid dysfunction.