Are we near the cure of genetic diseases and possibly cancers, in the advanced CRISPAR era??

Abstract

Sickle cells disease (SCD), a blood disorder which damages multiple organs and excruciating pains leads to multiple morbidities. SCD occurs because of the defect in HBB gene, single mutation in this gene leads to formation of haemoglobin S, which leads to sickling, sticky and crescent-shaped red blood cells in slight hypoxic conditions. Leading to strokes, heart attacks and other critical organs damages in multiple ways in multiple times over period of time. This increases morbidity and early mortality. As this is disease is recessively heritable from parents and high degrees of penetrance in off springs. This disease thought to have originated in Africa and have protective effects against endemic malaria.