Comparative Study of Magnesium Sulphate added to Bupivacaine and Ropivacaine Local Infiltration of Wound for Postoperative Analgesia in Patients Undergoing Upper Abdominal Surgery: A Randomized Double Blind Study

Abstract

Aim: To compare subcutaneous infiltration of Inj Bupivacaine with inj MgSO4and Inj Ropivacaine withInjMgSO4 for postoperative analgesia undergoing upper abdominal surgery. Goal: To determine duration ofanalgesia, doses of rescue analgesia, VAS at different time intervals.Background: Post-operative pain is most neglected entity. We should use availableresources inoptimummanner for improving pain managementstrategies.Methods: A Prospective, double-blinded, randomized studyof 50 patients undergoing upper abdominalsurgery divided into group B and R. Infiltration was done in the subcutaneous plane by surgeon before skinclosure. Group B: Inj. Bupivacaine 50mg (10ml of 0.5% Inj . Bupivacaine) with Inj.MgSO4 500mg (1ml ofInj 50% MgSO4) diluted with NS 9 ml to make total volume of 20 ml whereas, Group R: Inj Ropivacaine50 mg (6.7 ml of 0.75% Inj. Ropivacaine) with Inj MgSO4 500 mg diluted with NS (12.3 ml) making a totalvolume of 20 ml. In postoperative period, parameters noted were vitals and Visual Analogue Score (VAS)for 24 hours.Results: In group R, moderate pain was seen in 40%of the patients at T12 whereas in group B 48% hadmoderate pain. Total no. of rescue analgesic doses required in Group R is 2.1 +/- 0.5 and in Group B is 2.6+/- 0.5 in 24 hrs and has significant differencestatistically.Conclusion: Group R had better VAS scores at T24 and reduced no.of rescue analgesic doses.