Effect of Different Drugs on Diuretic Resistance Indices in Patients with Renal Impairment Using Intravenous Furosemide

Abstract

Chronic kidney disease is a medical condition defined as a reduction in kidney function, made known byglomerular filtration rate of a less than 60 mL/min per 1·73 m², or signs of kidney impairment (albuminuria),or both for at least three months period, nevertheless of the original cause.Diuretic resistance in the edematous patient is defined as a clinical state in which diuretic response isdiminished or lost before the therapeutic goal of relief from edema has been reached.This study aims to find the effect of different drugs on kidney functionindices and the relationship of usingthese drugs with the development or improvement of diuretic resistance.The study is a cross-sectional observational study. It was carried out at Al-Hussein-Teaching Hospital inThi-Qar. Nasiriya. Data from 104 patients were collected and analyzed using different statistical methods.The results showed that there was a different odd of effects of the drugs commonly used to patients withCKD due to other comorbidities on diuretic resistance indices. There was a significant increase in the bodyweight and decline in serum urea in patients already with edema when they used calcium ampoule. Serumurea was not affected by any of the other studied drugs. There were two drugs affected positively on serumcreatinine, which are clopidogrel and heparin. Albuminuria was highly improved in patients receivingaspirin and atorvastatin. Clopidogrel significantly increased GFR in these patients.