A Comparison Study of Adding Magnesium Sulfate to Local Anesthetics During Spinal Anesthesia for Cesarean Section

Abstract

Background: Regional anesthesia is frequently used in obstetric, orthopedic, and urological procedures,commonly intrathecal and epidural local anesthetics are combined with opioids to prolong analgesia; however,these do not prolong the motor block time and can attenuate the response to surgical stress, in addition tobeing associated with side effects such as respiratory depression, urinary retention, pruritus, hemodynamicinstability, nausea, and emesis. Objective: to investigate the effect of adding 75 mg ofmagnesium sulfate onthe duration of sensory block and duration of motor blockPatients and Methods: In a prospective randomized study, ASA I or II, 128 (64 control and 64 experimentalgroups) pregnant women (at term) who were candidate for cesarean section with spinal anesthesia, wererecruited in this study. They were collected from “Baghdad Teaching Hospital” at the period from (September2020 to Fab 2021).Each experimental woman received 12.5 mg (2.5 ml) of hyperbaric bupivacaine(0.5%) and 0.5 ml (75 mg) magnesium sulfate (15%), while controls received same does of hyperbaricbupivacaine and 0.5 ml of distilled water.Results: The duration of analgesia (sensory blockade) and theduration of motor blockade manifesteda statistically significant increase inexperimental as compared to their controls (control = 116.41 ±12.47,experimental = 159.75 ± 10.56, control = 180.76 ± 11.83, experimental = 240 ±9.46 minutesrespectively).Conclusion:Significantly increased the duration ofpostoperative analgesia and prolonged the sensory andmotor blockade withoutsignificant apparent maternal or fetal side effects.