Archive | 2019
Value of application of helicobacter pylori typing in recurrent abdominal pain in children
Abstract
Objective \nTo explore the value of applying helicobacter pylori typing in the diagnosis and treatment of children with recurrent abdominal pain (RAP). \n \n \nMethods \n140 children with RAP and highly suspicious of gastritis were selected as an experimental group, and 140 children taking physical examination at the same time as a control group. 13C-UBT were performed in both groups, and their H.pylori positive rates were represented with P1 and P2. The children with H.pylori (+) in the experimental group took serotyping detection (type Ⅰ, type Ⅱ, and middle type), and were performed gastroscopy at the same time; according to the degree of gastric mucosal lesions under gastroscope they were divided into a mild inflammation group, a moderate inflammation group, and a severe inflammation group. The children who had type Ⅰ or middle type H.pylori infection were given standard triple therapy for 10 days; and after 4 weeks’ therapy they were rechecked by 13C-UBT, and their eradication rates were represented by P3 and P4, respectively. \n \n \nResults \nP1>P2 and P4>P3; there were statistical differences (P<0.05). Type Ⅰ was associated with severe gastritis, type Ⅱ with mild gastritis, and middle type with moderate gastritis. \n \n \nConclusion \nRAP is closely related to H. pylori infection; helicobacter pylori typing can help preliminarily understand the degree of gastric mucosal lesions in children with with RAP, and provide guidance for further gastroscopy. In addition, different treatment regimens for different types of H.pylori may significantly alleviate the abdominal pain of RAP children. \n \n \nKey words: \nHelicobacter pylori;\xa0Typing test;\xa0Recurrent abdominal pain;\xa0Children;\xa0Application value