Changes of hemoglobin levels after chemotherapy in patients with ovarian cancer and influence of anemia on prognosis

Abstract

Objective \nTo investigate the changes of hemoglobin levels in patients with ovarian cancer after chemotherapy and the influence of anemia on the prognosis of patients. \n \n \nMethods \nA total of 73 patients with ovarian cancer were selected. SPSS 25.0 statistical software was used to analyze the changes of hemoglobin levels after chemotherapy. According to the hemoglobin content before chemotherapy, the patients were divided into anemia group (Hb>110 g/L) and non-anemia group (Hb<110 g/L). Log Rand was used to compare the difference of survival time between the two groups. COX model was used to analyze the related factors affecting the prognosis of ovarian malignant tumors. \n \n \nResults \nThe hemoglobin content before and after six chemotherapy cycles were (108.24±18.09)g/L and (100.17±21.06)g/L respectively, with significant difference (P=0.021). The incidence of anemia and the degree of anemia gradually increased. The rate of anemia after six cycles of chemotherapy was higher than before chemotherapy, with significant difference (P=0.027). Survival analysis showed that progression free survival (PFS) was significantly lower in the anemic group than in the non-anemic group (P=0.01). COX regression analysis showed that anemia, postoperative residual lesion size, and surgical clinical staging were independent factors affecting the prognosis of patients with ovarian malignant tumors. \n \n \nConclusions \nChemotherapy reduces the hemoglobin content in patients with ovarian malignant tumors and aggravates anemia. Anemia affects the survival rate of patients with ovarian malignant tumors and is an independent factor affecting the prognosis of patients. \n \n \nKey words: \nOvarian neoplasms;\xa0Antineoplastic combined chemotherapy protocols;\xa0Hemoglobinometry;\xa0Anemia