Meta-analysis on modified Zuogui Pill combined with hormone in the treatment of premature ovarian failure

Abstract

Objective \nTo evaluate the effectiveness and safety of modified Zuogui Pill combined with hormone in the treatment of premature ovarian failure (POF). \n \n \nMethods \nRandomized controlled trials were carried out by searching Chinese and English databases from the establishing to June, 2018. The methodological quality was assessed in the included randomized controlled trials. The treatment of premature ovarian failure by modified Zuogui Pill combined with hormone was systematically evaluated by RevMan 5.3 software. \n \n \nResults \n11 randomized controlled trials involving 1 004 patients were included. Meta-analysis results showed that total effective rate (OR=4.44, 95% CI: 3.10-6.36, P<0.00001), Tranditional Chinese Medcine (TCM ) syndromes (including dizziness, tinnitus, hot flash night sweats, five upset fever, waist and knees), serum follicle stimulating hormone (FSH) level [standardised mean difference(SMD)=0.54, 95% CI: 0.13-0.95, P=0.01], luteinizing hormone (LH) level (SMD=0.90, 95% CI: 0.45-1.36, P<0.0001), estradiol (E2 )level (SMD=1.26, 95% CI: 0.12-2.40, P=0.03), endometrial thickness [weighted mean difference (WMD)=2.03, 95% CI: 0.07-3.99, P=0.04] improvement and the incidence of adverse reactions (OR=0.34, 95% CI: 0.12-0.95, P=0.04) in modified Zuogui Pill combined with hormone therapy were superior to those of pure hormone therapy. \n \n \nConclusions \nThe modified Zuogui Pill combined with hormone therapy shows better therapeutic effect and safety than hormone therapy on premature ovarian failure. \n \n \nKey words: \nPrimary ovarian insufficiency;\xa0ZUOGUI PILL;\xa0Hormone replacement therapy;\xa0Meta-analysis