Effect of remifentanil combined with propofol on anesthesia in gynecological laparoscopic surgery

Abstract

Objective \nTo study the effect of remifentanil combined with propofol target-controlled infusion on anesthesia of gynecological laparoscopic surgery. \n \n \nMethods \nFrom August 2016 to August 2018, 132 patients who needed to undergo gynecological laparoscopy in the Maternal and Child Health Care Hospital of Qujing were selected.The patients were randomly divided into two groups according to the principle of simple randomization, with 66 cases in each group.The observation group was given.remifentanil combined with propofol administered by target-controlled infusion for anesthesia.The control group were given fentanyl intravenous anesthesia.The clinical efficacy of the two groups was observed. \n \n \nResults \nThe onset time of anesthesia[(1.3±0.3)min], awake time[(5.2±1.5)min], anesthesia recovery time[(19.6±5.3)min]and analgesic time[(23.6±3.5)min]in the observation group were all shorter than those in the control group[(3.1±0.6)min, (5.0±3.5)min, (4.06±4.8)min, (48.3±4.4)min](t=12.742, 15.102, 11.265, 12.354, all P<0.0). At 1 min after hemodynamic intubation, 10 min after pneumoperitoneum, 30 min after operation and 30min after operation, the heart rate, systolic blood pressure (SBP) and diastolic blood pressure (DBP) in the observation group were (82.38±7.45)times/min, (85.65±8.54)times/min, (77.58±8.65)times/min, (80.12±7.77)times/min, SBP: (136.25±20.14)mmHg, (140.36±18.02)mmHg, (129.14±15.24)mmHg, (131.25±16.19)mmHg, DBP: (986.45±11.02)mmHg, (86.59±10.11)mmHg, (80.17±8.29)mmHg, (82.52±8.17)mmHg, which were better than those in the control group[herat rate: (88.14±10.01)times/min, (95.36±8.48)times/min, (86.58±7.33)times/min, (87.48±8.47)times/min; SBP: (140.28±21.57)mmHg, (144.59±21.35)mmHg, (137.33±18.47)mmHg, (136.25±18.47)mmHg; DBP: (90.0±10.14)mmHg, (90.25±11.24)mmHg, (84.25±10.14)mmHg, (82.55±8.84)mmHg](F=1.320, 1.245, 1.365, all P<0.05). \n \n \nConclusion \nRemifentanil combined with propofol target controlled infusion for patients undergoing gynecological laparoscopic surgery is helpful to enhance the anesthetic effect, and has a short pharmacodynamic effect, which is conducive to ensuring the quality of surgery.Therefore, it is worthy of popularizing in clinical practice. \n \n \nKey words: \nremifentanil;\xa0Propofol;\xa0Gynecological surgical procedures;\xa0Laparoscopy;\xa0Anesthesia