Effects of Xueshuantong and alprostadil combined with hyperbaric oxygen on hemodynamics and serum inflammatory indexes in elderly patients with peripheral arterial disease

Abstract

Objective \nTo analyze the effects of Xueshuantong and alprostadil combined with hyperbaric oxygen (HBO) on clinical efficacy, hemodynamics and serum inflammatory indexes in elderly patients with lower extremity arteriosclerosis occlusion. \n \n \nMethods \nOne hundred and eighteen patients with lower extremity arteriosclerosis occlusion admitted into the surgical department of the hospital from May 2017 to January 2019 were randomly divided into the combined medication group (n=59) and the control group (n=59). The control group was just treated with alprostadil injection, while the combined medication group was treated with Xueshuantong and alprostadil combined with HBO treatment. Clinical efficacy after treatment, changes in atherosclerosis indexes, hemodynamic indexes (whole blood viscosity, plasma viscosity and fibrinogen), the levels of serum inflammatory indexes, such as hs-CRP, interleukin-6, interleukin 8 and tumor necrosis factor-α(TNF-α) before and after treatment were compared between the patients of the 2 groups. \n \n \nResults \nThe total effective rate of the combined medication group was 93.22%, which was significantly higher than 79.66% of the control group(P<0.05). The blood flow of dorsal pedal artery, ankle-brachial indexes and toe-brachial indexes in the patients of the 2 groups after treatment were all significantly higher than those before treatment (P<0.05), and the combined medication group was obviously superior to the control group, with statistical significance (P<0.05). The whole blood viscosity, plasma viscosity and fibrinogen (FIB) levels in the patients of the 2 groups after treatment all significantly decreased as compared with those before treatment (P<0.05), and the indexes of the combined medication group were significantly lower than those of the control group, also with statistical significance(P<0.05). The levels of TNF-a, hs-CRP, IL-6 and IL-8 in the patients of the 2 groups after treatment were significantly lower than those before treatment (P<0.05), and the combined medication group was also obviously superior to the control group, with statistical significance (P<0.05). \n \n \nConclusion \nXueshuantong and alprostadil combined with HBO in the treatment of elderly patients with peripheral arterial disease (PAD) could achieve significant clinical effects, and in the meantime could evidently delay the occurrence of lower extremity arteriosclerosis, improve hemodynamics, relieve inflammation reactions. For this reason, it is worth further clinical extension. \n \n \nKey words: \nXueshuantong;\xa0Alprostadil;\xa0Hyperbaric oxygen;\xa0Lower extremity arteriosclerosis occlusion;\xa0Hemodynamics;\xa0Serum inflammatory indicators