Correlation between serum gelsolin and complement C9 levels and pulmonary tuberculosis lesions invading pleura

Abstract

Objective \nTo investigate the correlation between serum gelsolin and complement C9 levels and pulmonary tuberculosis lesions invading pleura. \n \n \nMethods \n100 newly treated patients with secondary pulmonary tuberculosis in Shaanxi Provincial Tuberculosis Prevention and Control Hospital from January 2017 to December 2018 were divided into non-invasive pleural group (n=37) and invasive pleural group (n=63). Serum gelsolin level was detected by ELISA and serum complement C9 level was detected by immunoturbidimetry.Logistic stepwise regression analysis was used to screen the influencing factors of tuberculosis lesions invading pleura.ROC curve was used to analyze the efficacy of complement gelsolin and C9 in diagnosing tuberculosis lesions invading pleura. \n \n \nResults \nThe levels of albumin and IGRA in invasive pleura group were lower than those of in non-invasive pleura group (t=12.274, 10.917, both P<0.05). The positive rate of sputum bacteria and the levels of gelsolin and complement C9 in invasive pleura group were higher than those of in non-invasive pleura group (χ2=5.420, t=61.230, 21.195, all P<0.05). Serum gelsolin and complement C9 levels were positively correlated with pleural invasion area, IGRA and sputum bacteria (r=0.851, 0.492, 0.695, 0.641, 0.430, 0.510, all P<0.05). Serum gelsolin, complement C9 and positive sputum bacteria were risk factors for tuberculosis lesions invading pleura (OR=3.315, 1.706, 1.408, all P<0.05). The area under ROC curve (AUC) of serum gelsolin, complement C9 and sputum bacterium in diagnosis of tuberculosis lesions invading pleura were 0.88, 0.74 and 0.89 respectively, which had certain diagnostic value.Compared with the AUC of three groups, sputum bacterium examination was the largest, gelsolin was the second and complement C9 was the smallest, but there was no significant difference between sputum bacterium examination and gelsolin′s AUC.The sensitivity and specificity of sputum bacterium examination were the highest, 76.64% and 95.65% respectively. \n \n \nConclusions \nThe serum levels of gelsolin and complement C9 are high in patients with pulmonary tuberculosis invading pleura, which are correlated with pulmonary tuberculosis invading pleura.Both can be used as an auxiliary diagnostic index for pulmonary tuberculosis invading pleura. \n \n \nKey words: \nTuberculosis, pulmonary;\xa0Gelsolin;\xa0Complement C9;\xa0Correlation