Effects of atomizing inhalation of alprostadil on pulmonary oxygenation function after one lung ventilation

Abstract

Objective \nTo observe the effects of atomizing inhalation of alprostadil on pulmonary oxygenation function after one lung ventilation (OLV). \n \n \nMethods \nForty-two patients with thoracic esophageal cancer undergoing elective resection were enrolled in the study and divided into two groups (n=21): a test group (group T) and a control group (group C) according to the random number table. When OLV started, group T received atomizing inhalation of alprostadil 0.2 μg/kg via the left lung, while group C received the same amount of normal saline. Radial arterial blood samples were taken 3 min before OLV (T1), 3 min after OLV (T2), and 30 min after T2(T3) for blood gas analysis and oxygenation index (OI) and pulmonary shunt rate (Qs/Qt) were calculated. The hemodynamic indexes of the two groups were recorded at these points. \n \n \nResults \nPatients in both groups presented remarkable decreases in OI values and marked increases in Qs/Qt at T2 and T3 compared with those at T1(P 0.05). \n \n \nConclusions \nAtomizing inhalation of alprostadil during OLV towards ventilated lungs can improve oxygenation function and decrease intrapulmonary shunt in patients after OLV. \n \n \nKey words: \nOne lung ventilation;\xa0Alprostadil;\xa0Oxygenation function