Chinese Journal of Modern Nursing | 2019
Catheter pretreatment on the prevention of phlebitis induced by PICC: a network Meta-analysis
Abstract
Objective \nTo explore the effect of catheter pretreatment on the prevention of PICC phlebitis, the best solution of catheter pretreatment was obtained by network Meta-analysis. \n \n \nMethods \nThe databases of PubMed, Web of Science, EMBASE, Cochrane Library, EBSCO, CNKI, VIP, and Wanfang were searched by computer and analyzed by Stata14.0 software. \n \n \nResults \nA total of 16 randomized controlled trials, including 3 998 patients, involved 12 catheter pretreatment solutions. The forest map showed that the difference between normal saline and 0.125 mg/ml dexamethasone solution, 50 U/ml heparin sodium+0.25 mg/ml dexamethasone mixture, 0.08 mg/ml dexamethasone solution, 50 U/ml heparin sodium solution, 0.05 mg/ml dexamethasone solution and 1.67 mg/ml dexamethasone solution was statistically significant (P< 0.05) . There was statistically significant difference between 0.04 mg/ml dexamethasone solution and 0.125 mg/ml dexamethasone solution, 0.08 mg/ml dexamethasone solution, 0.05 mg/ml dexamethasone solution and 1.67 mg/ml dexamethasone solution (P< 0.05) . The results of area plot under cumulative sorting probability curve showed that the following four kinds of catheter pretreatment solutions had better effect on preventing PICC phlebitis: 1 600 U/ml gentamicin + 0.125 mg/ml dexamethasone solution, 50 U/ml heparin sodium+0.25 mg/ml dexamethasone mixture, 0.05 mg/ml dexamethasone solution and 50 U/ml heparin sodium solution. \n \n \nConclusions \nBased on the results of network Meta-analysis and the results of Sucra sequencing, the catheter pretreatment solution is closely related to the occurrence of phlebitis, 1 600 U/ml gentamicin + 0.125 mg/ml dexamethasone solution, 50 U/ml heparin sodium+0.25 mg/ml dexamethasone mixture, 0.05 mg/ml dexamethasone solution and 50 U/ml hepatic sodium solution are better than other pretreatment solutions in the prevention of phlebitis, but large samples are still needed to verify. \n \n \nKey words: \nPeripherally inserted central catheter;\xa0Phlebitis;\xa0Pretreatment;\xa0Network Meta-analysis