Comparative analysis on effects between high-flux hemodialysis and routine hemodialysis on chronic uremia

Abstract

Objective \nTo analyse the effects of high-flux hemodialysis and routine hemodialysis on patients with chronic uremia. \n \n \nMethods \nEighty patients with chronic uremia who were treated in the Fifth People’s Hospital of Datong from June 2016 to June 2018 were enrolled in the study. The patients were divided into control group and observation group by random number table method, with 40 cases in each group. Patients in control group were treated by routine hemodialysis, while patients in observation group were treated by high-flux hemodialysis. The related indexes of the two groups were compared before and after hemodialysis, and incidences of complications were compared between the two group, such as infection and hypotension. \n \n \nResults \nAfter treatment, there was no significant difference in blood urea nitrogen (BUN), serum creatinine (Scr), K+ or other indexes between the two groups (P>0.05). The parathyroid hormone (IPTH) and β2-microglobulin (β2-MG) of observation group were significantly lower than those of control group, and hemoglobin (Hb) level was higher than that of control group (P<0.05). The incidence of adverse reactions during hemodialysis in control group (25.0%) was higher than that in observation group (7.5%), and the difference was significant (P<0.05). \n \n \nConclusions \nCompared with conventional hemodialysis, high-flux hemodialysis has better scavenging effects on macromolecular toxins, and it can reduce dialysis-related complications, which is an effective treatment for chronic uremia. \n \n \nKey words: \nChronic uremia;\xa0High-flux hemodialysis;\xa0Routine hemodialysis;\xa0Adverse reactions