Archive | 2019
Clinical observation of methylprednisolone sodium succinate for injection combined with ganciclovir in the treatment of severe viral meningitis
Abstract
Objective \nTo investigate the value of methylprednisolone sodium succinate for injection combined with ganciclovir in the treatment of severe viral meningitis. \n \n \nMethods \nNinety-eight patients with severe viral meningitis from January 2016 to February 2018 were enrolled in Shanxi Coal Central Hospital. The patients were divided into observation group and control group according to the random number table method, with 49 cases in each group. On the basis of routine treatment, the control group was treated with ganciclovir + dexamethasone, while the observation group was treated with ganciclovir + methylprednisolone sodium succinate for injection. The clinical efficacy, symptoms and signs, serum inflammatory factors [procalcitonin (PCT), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-8 (IL-8)] levels and functional scores [neurological function (NIHSS score), motor function (Fugl-Meyer score), activity of life (ADL score) changes before and after treatment were compared between the two groups. The incidences of adverse reactions during treatment were compared between the two groups. \n \n \nResults \nâ‘ Clinical efficacy: the total effective rate of observation group was 91.84% (45/49), which was higher than that of control group [75.51% (37/49), P 0.05). \n \n \nConclusions \nThe effect of methylprednisolone sodium succinate for injection combined with ganciclovir on severe viral meningitis is remarkable, which is beneficial to alleviating clinical symptoms and signs, reducing the degree of inflammation reaction, improving the functional status of patients, with certain safety. \n \n \nKey words: \nSevere viral meningitis;\xa0Ganciclovir;\xa0Methylprednisolone sodium succinate for injection;\xa0Inflammatory factors;\xa0Neurological function