Current research progress of coronary in-stent restenosis

Abstract

Percutaneous coronary intervention is one of the effective treatment methods for coronary heart disease. Although the use of coronary stent brought a dramatic improvement in patients’ angiographic and clinical outcomes, but the long-term outcomes of stent implantation were still significantly constrianed by the risk of developing in-stent restenosis (ISR) over time. The mechanism of ISR is complex and not yet clear, mainly results from aggressive neointimal proliferation and neoatherosclerosis. Current study suggests that repeat transplanting second-generation stent or drug-eluting balloon is most likely to be the best strategy, and bioresorbable vascular stent also is one of the safe techniques \n \n \nKey words: \nIn-stent restenosis;\xa0Mechanism;\xa0Second-generation stent;\xa0Drug-eluting balloon;\xa0Bioresorbable vascular scafflod