Clinical effects of modified pulmonary infection control window guided invasive-noninvasive sequential ventilation in the treatment of acute exacerbation chronic pulmonary disease with respiratory failure

Abstract

Objective \nTo investigate the clinical effects of modified pulmonary infection control window guided invasive-noninvasive sequential ventilation in the treatment of acute exacerbation chronic pulmonary disease (AECOPD) with respiratory failure. \n \n \nMethods \nFifty AECOPD patients with respiratory failure treated in Xuzhou First People’s Hospital from January 2015 to June 2018 were selected and divided into observation group and control group by random number table method. The control group was given tracheal intubation and mechanical ventilation, while the observation group was given invasive-noninvasive sequential ventilation under the guidance of improved pulmonary infection control window. The therapeutic effects of the two groups were compared. \n \n \nResults \nThe total hospitalization time, total mechanical ventilation time, invasive mechanical ventilation time and intensive care unit stay time in the observation group were shorter than those in the control group (P<0.05). And the respiratory rate, heart rate and ventilation-associated pneumonia incidence were less than those in the control group (P<0.05). After treatment, the levels of partial pressure of oxygen in arterial blood, pH and end-tidal carbon dioxide tension in both groups increased (P<0.05); while partial pressure of carbon dioxide in arterial blood decreased, and the changes in the observation group were more significant (P<0.05). Forced expiratory volume in 1 second, forced expiratory flow at 25% to 50% increased significantly after treatment, and the increases in the observation group were more significant (P<0.05). \n \n \nConclusions \nModified pulmonary infection control window guided invasive-noninvasive sequential ventilation is effective in the treatment of AECOPD with respiratory failure. It can improve pulmonary ventilation and blood gas index, alleviate inflammatory response, and effectively improve prognosis. \n \n \nKey words: \nPulmonary infection control window;\xa0Invasive-noninvasive sequential ventilation;\xa0Acute exacerbation chronic pulmonary disease with respiratory failure