Archive | 2019
Effects of non-pharmacological interventions on relevant indicators of pre-diabetes in China: a network Meta-analysis
Abstract
Objective \nTo evaluate the intervention effects of diet, exercise and health education on pre-diabetes in China by network meta-analysis. \n \n \nMethods \nA systematic search of CNKI, Wan-Fang, VIP, PubMed, Springer Link, Proquest, Highwire press, Uptodate, Cochrane database was carried out. Randomized control trials examining the influence of non-drug intervention on pre-diabetes in China were included. The data of prevalence rate, fasting plasma glucose (FPG), 2-hour postprandial plasma glucose (PPG) were analyzed by ADDIS 1.16.6. The count data were used the odds ratio (OR) and its 95% CI, and the measurement data were used the standardized mean difference (SMD) and its 95%CI as the efficacy analysis statistics. The results of each intervention were evaluated visually using rank probability. \n \n \nResults \nA total of 14 studies were included. The potential scale reduced factor of all the three outcomes was close to 1 in the presence of good convergence and consistence (P>0.05). Dietary intervention was better than health education and exercise intervention in prevalence rate[OR(95%CI): 1.44(0.20, 11.69) and 1.94(0.42,8.82), respectively]. Dietary intervention was better than health education and exercise intervention in FPG[SMD(95% CI): 0.07(-0.43, 0.52) and 0.32(-0.38, 0.94), respectively]. Health education was better than dietary intervention and exercise intervention in PPG[SMD(95% CI): 0.62(-0.91, 2.19) and 0.81(-1.70, 3.44), respectively]. The rank probability showed that dietary intervention was better than others in prevalence rate and FPG, health education was better than others in 2PPG. \n \n \nConclusion \nMedical intervention may focus on dietary intervention among pre-diabetes in China. \n \n \nKey words: \nPrediabetic state;\xa0Meta-analysis;\xa0Health education;\xa0Diet therapy;\xa0Exercise therapy