Correlation analysis of serum retinol binding protein 4 and serum Lipasin level with vascular complications in gestational diabetes mellitus

Abstract

Objective \nTo explore the relationship between serum retinol binding protein 4 and serum Lipasin levels and vascular complications in gestational diabetes mellitus (GDM) . \n \n \nMethods \nFrom Jan. 2016 to Jan. 2018, 80 pregnant women with gestational diabetes diagnosed as GDM in Wenzhou Central Hospital of Zhejiang Province were selected as the study group. They were divided into two groups according to whether they had vascular lesions. Group A included patients with gestational diabetes mellitus complicated with vascular complications and group B included patients without vascular complications. Forty healthy pregnant women were selected as the control group (group C) . The levels of fasting plasma glucose (FPG) , fasting serum insulin (FINS) , homeostatic model assessment of insulin resistance (HOMA-IR) , serum retinol binding protein 4 (RBP4) and serum Lipasin were compared among three groups of pregnant women. The vascular complications of GDM were analyzed. \n \n \nResults \nThe levels of FPG, FINS and HOMA-IR in gestational diabetes mellitus pregnant women were higher than those in healthy pregnant women (P<0.05) , and those in group A were higher than those in group B (P<0.05) . The levels of RBP4 and Lipasin in serum of pregnant women with GDM were higher than those of healthy pregnant women (P<0.05) , and those of group A were higher than those of group B (P<0.05) . Spearman univariate correlation analysis showed that serum RBP4 levels were positively correlated with FPG and FINS (P<0.05) , and serum Lipasin levels were positively correlated with FPG and FINS (P<0.05) . Logistic regression analysis showed that the levels of FPG, FINS, RBP4 and Lipasin increased, which were independent risk factors for diabetic retinopathy (P<0.05) . \n \n \nConclusion \nIn GDM with vascular complications, the serum RBP4 and Lipasin levels are higher, which are independent risk factors for vascular complications in GDM, and may participate in the occurrence and development of vascular complications in gestational diabetes mellitus. \n \n \nKey words: \nRetinol binding protein 4;\xa0Lipasin;\xa0Gestational diabetes mellitus;\xa0Vascular complications